MovDisordV3, France, Analysis, bibRecord, 000488

Fetal neural grafts for Huntington's disease: A prospective view

Identifieur interne : 000488 ( France/Analysis ); précédent : 000487; suivant : 000489

Fetal neural grafts for Huntington's disease: A prospective view

Auteurs : Anne-Catherine Bachoud-Lévi [France] ; Philippe Hantraye [France] ; Marc Peschanski [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2002-05.

RBID : ISTEX:E2AD65FFE6CA6B8C1AA65A758F8EA6B20D39E170

English descriptors

KwdEn :
- Animals, Brain Tissue Transplantation, Clinical Trials as Topic, Corpus Striatum (transplantation), Female, Fetal Tissue Transplantation, Humans, Huntington Disease (surgery), Nerve Tissue (embryology), Pregnancy, Treatment Outcome, cell therapy, clinical trial, neurodegenerative disease.
MESH :
- embryology : Nerve Tissue.
- surgery : Huntington Disease.
- transplantation : Corpus Striatum.
- Animals, Brain Tissue Transplantation, Clinical Trials as Topic, Female, Fetal Tissue Transplantation, Humans, Pregnancy, Treatment Outcome.

Abstract

Intrastriatal transplantation of striatal neuroblasts from human fetuses is a promising approach for treatment of Huntington's disease, on the basis of many experimental animal studies and, most recently, pilot clinical trials. Technically, several issues remain to be resolved (e.g., the precise site of dissection of the fetal tissue; the number and location of the fetal striatal implants; or the use of immunosuppressive therapy), and await larger‐scale trials and purposely designed protocols. Further clinical data must also be obtained, and preliminary promising results must be replicated in a patient group large enough to provide conclusive results. It is important to establish (1) the amount of clinical benefit provided to the patient by the grafted cells; (2) the anticipated duration of clinical benefits; and (3) the secondary rate of decline after the benefit of the graft has been overbalanced. Evaluation of these parameters will require very long‐term follow‐up of the patients involved, over several years after grafting, before the technique can eventually be proposed widely to patients. © 2002 Movement Disorder Society

Url:

https://api.istex.fr/document/E2AD65FFE6CA6B8C1AA65A758F8EA6B20D39E170/fulltext/pdf

DOI: 10.1002/mds.10117

Affiliations:

Links to Exploration step

ISTEX:E2AD65FFE6CA6B8C1AA65A758F8EA6B20D39E170

Le document en format XML

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<front><div type="abstract" xml:lang="en">Intrastriatal transplantation of striatal neuroblasts from human fetuses is a promising approach for treatment of Huntington's disease, on the basis of many experimental animal studies and, most recently, pilot clinical trials. Technically, several issues remain to be resolved (e.g., the precise site of dissection of the fetal tissue; the number and location of the fetal striatal implants; or the use of immunosuppressive therapy), and await larger‐scale trials and purposely designed protocols. Further clinical data must also be obtained, and preliminary promising results must be replicated in a patient group large enough to provide conclusive results. It is important to establish (1) the amount of clinical benefit provided to the patient by the grafted cells; (2) the anticipated duration of clinical benefits; and (3) the secondary rate of decline after the benefit of the graft has been overbalanced. Evaluation of these parameters will require very long‐term follow‐up of the patients involved, over several years after grafting, before the technique can eventually be proposed widely to patients. © 2002 Movement Disorder Society</div>
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Movement Disorders (revue)

Fetal neural grafts for Huntington's disease: A prospective view

Fetal neural grafts for Huntington's disease: A prospective view

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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